Abstract
Cys-loop receptors (CLRs) or pentameric ligand-gated ion channels (pLGICs) are a class of integral membrane proteins involved in fast excitatory or inhibitory synaptic neurotransmission. Known representatives of the family are the nicotinic acetylcholine receptor (nAChR), the serotonin-3 receptor (5-HT3R), the glycine receptor (GlyR) and the subtype A/C γ-aminobutyric acid receptor (GABAA/CR). Over the last years, important structural information emerged with the structure determination of the β3 GABAR, the 5-HT3AR, the α1 and α3 GlyR and the α4β2 nAChR.
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