Abstract
(1) This paper further examines the functional characteristics of recombinant human GABA A receptors containing the ϵ-subunit expressed in Xenopus oocytes. (2) α1 β1 ϵ receptors are not modulated by benzodiazepine ligands or by a number of hypothalamic hormones. (3) The intravenous anaesthetic agents pentobarbital, propofol and etomidate all potentiate sub-maximal GABA currents (EC 20) to a similar degree in α1 β1 ϵ and α1 β1 γ2s receptors. (4) Direct activation by pentobarbital produced a similar maximum response on α1 β1 ϵ and α1 β1 γ2s, however, both the EC 50 and slope were lower on α1 β1 ϵ compared to α1 β1 γ2s. (5) These results describe a novel pharmacology for recombinant α1 β1 ϵ receptors.
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