Functional Biomaterials for Treatment of Chronic Wound.

Xi Zhang,Wentao Shu,Wenrui Qu,Rui Li,Qinghua Yu,Yinan Wang

doi:10.3389/fbioe.2020.00516

Abstract

The increasing number of patients with chronic wounds caused by diseases, such as diabetes, malignant tumors, infections, and vasculopathy, has caused severe economic and social burdens. The main clinical treatments for chronic wounds include the systemic use of antibiotics, changing dressings frequently, operative debridement, and flap repair. These routine therapeutic strategies are characterized by a long course of treatment, substantial trauma, and high costs, and fail to produce satisfactory results. Biomaterial dressings targeting the different stages of the pathophysiology of chronic wounds have become an active research topic in recent years. In this review, after providing an overview of the epidemiology of chronic wounds, and the pathophysiological characteristics of chronic wounds, we highlight the functional biomaterials that can enhance chronic wound healing through debridement, anti-infection and antioxidant effects, immunoregulation, angiogenesis, and extracellular matrix remodeling. It is hoped that functional biomaterials will resolve the treatment dilemma for chronic wounds and improve patient quality of life.

Highlights

Owing to an increasing number of patients with chronic diseases such as diabetes, there are more than 6.5 million patients with chronic wounds worldwide, and the overall medical cost for treating chronic wounds exceeds 25 billion US dollars per year (Sen et al, 2009)
We focus on research progress with respect to biomaterials used for debridement and to achieve anti-infection and antioxidation effects, immunoregulation, angiogenesis, and extracellular matrix (ECM) remodeling in chronic wounds
Reduced the area of chronic ulcers and effectively reduced pain The antioxidant PPCN hydrogel could promote epidermal and appendage regeneration, combined with stromal cell derived factor-1 (SDF-1) to further improve the repair effect; wounds were closed by day 24 The therapeutic effect was dose-dependent, which proved the dual role of ROS in chronic wound healing

Summary

Introduction

Owing to an increasing number of patients with chronic diseases such as diabetes, there are more than 6.5 million patients with chronic wounds worldwide, and the overall medical cost for treating chronic wounds exceeds 25 billion US dollars per year (Sen et al, 2009). We focus on research progress with respect to biomaterials used for debridement and to achieve anti-infection and antioxidation effects, immunoregulation, angiogenesis, and extracellular matrix (ECM) remodeling in chronic wounds. Protease loaded polyacrylate-based dressing can achieve effective debridement of chronic wounds (Humbert et al, 2014).

Results

Conclusion