Abstract
Measles virus (MV) exhibits a very limited host range. Humans are the only known reservoir, although the virus can infect some monkey species. In the laboratory, the virus produces characteristic multinucleated giant cells and intracellular inclusion bodies when grown in a variety of human and simian cell cultures, thereby confirming this host specificity. The cytopathic affects are the result of a chain of events. Attachment of the virus is followed by a replicative cycle and the release of virus particles at the cell membrane. These steps all involve specific interaction of virus proteins, either between themselves or with cellular proteins. In this review we shall emphasize the importance of these protein-protein interactions for the function of the envelope-associated MV proteins. The inability of certain virus isolates, such as strains from subacute sclerosing panencephalitis (SSPE) patients, to sustain one or more of these interactions leads to incomplete or defective persistent infections in which virus particles are not formed.
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