Abstract
BackgroundRheumatoid arthritis (RA) and osteoarthritis (OA) are two major types of joint diseases that share multiple common symptoms. However, their pathological mechanism remains largely unknown. The aim of our study is to identify RA and OA related-genes and gain an insight into the underlying genetic basis of these diseases.MethodsWe collected 11 whole genome-wide expression profiling datasets from RA and OA cohorts and performed a meta-analysis to comprehensively investigate their expression signatures. This method can avoid some pitfalls of single dataset analyses.Results and ConclusionWe found that several biological pathways (i.e., the immunity, inflammation and apoptosis related pathways) are commonly involved in the development of both RA and OA. Whereas several other pathways (i.e., vasopressin-related pathway, regulation of autophagy, endocytosis, calcium transport and endoplasmic reticulum stress related pathways) present significant difference between RA and OA. This study provides novel insights into the molecular mechanisms underlying this disease, thereby aiding the diagnosis and treatment of the disease.
Highlights
Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease that mainly affects the flexible joints
Short Overview of the Studies Included In recent years, many studies have used microarray technology to analyzed the whole genome expression proofing in samples of RA and OA
Among the 11 datasets, nine studies focused on synovial tissues and two studies focused on peripheral blood and bone marrow-derived mononuclear cells, respectively
Summary
Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease that mainly affects the flexible joints. It is characterized by the inflammation of articular synovial. It is generally believed that the pathogenesis of RA is closely related to genetic factors Certain genes such as the human leukocyte antigen (HLA). HLA-DR4 and DW4 antigen, were identified in more than 90% of the patients These pathological factors are referred to as the RA-shared epitope [3,9]. Rheumatoid arthritis (RA) and osteoarthritis (OA) are two major types of joint diseases that share multiple common symptoms. The aim of our study is to identify RA and OA related-genes and gain an insight into the underlying genetic basis of these diseases
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