Abstract
The changes that occur at the level of the skin microvessels reflect changes at other microvessels including the cardiac microvessels. Several disease states seem to alter skin microvascular function and structure such as diabetes, hypertension, and hypercholesterolemia. Many of these disease states are frequently encountered in hemodialysis (Hdx) patients. The process of Hdx itself is also associated with vascular abnormalities. It was thus the aim of our study to examine the structure and function of skin microcirculation in Hdx patients. Sixty patients were examined: 20 patients on regular Hdx, younger than 60 years old, with no diabetes, hypertension, or hypercholesterolemia, 20 patients on regular hemodialysis with coexisting hypertension (Htn-Hdx), and 20 young healthy volunteers. The skin microcirculation was assessed using the laser Doppler fluxmetry and the capillaroscope. Results showed significant differences in the laser Doppler fluxmetry measurements between the Hdx group and the Htn-Hdx group compared with the control group, with no significant differences in the capillaroscope study. The study of skin microcirculation in Hdx patients indicated the presence of functional abnormalities without significant structural changes.
Highlights
The study of skin microcirculatory abnormalities represents a safe and easy tool to assess vascular abnormalities
Using laser Doppler fluxmetry (LDF) and capillaroscopy, many studies found a positive correlation between skin microcirculatory dysfunction and other vascular diseases [1,2] and the risk of development of heart disease [3,4].The aim of our study was to examine skin microcirculation in hemodialysis (Hdx) patients and compare this with a group of young healthy adults as a control
LDF is commonly used for the study of the functional abnormalities of the skin microcirculation, [5], whereas the capillaroscope is used for direct visualization of structural capillary abnormalities [6]
Summary
The study of skin microcirculatory abnormalities represents a safe and easy tool to assess vascular abnormalities. LDF is commonly used for the study of the functional abnormalities of the skin microcirculation, [5], whereas the capillaroscope is used for direct visualization of structural capillary abnormalities [6]. We will use both techniques to evaluate skin microcirculation in Hdx patients. The process of Hdx itself is associated with vascular abnormalities It was the aim of our study to examine the structure and function of skin microcirculation in Hdx patients. The skin microcirculation was assessed using the laser Doppler fluxmetry and the capillaroscope
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