Abstract
Embryonic chick sensory neurons grown in dissociated cell culture exhibit two functional responses to GABA: an increase in resting membrane permeability to chloride (Cl) ions (resulting in membrane depolarization) and a decrease in voltage-dependent calcium (Ca) channel current (resulting in a decreased action potential duration). These two functional effects differ in a number of ways. (1) The increase in resting membrane permeability desensitizes in the maintained presence of GABA, while the decrease in action potential duration does not. (2) Muscimol is a selective agonist for the increase in resting conductance, while baclofen is a selective agonist for the decrease in action potential duration. (3) Bicuculline inhibits the GABA- or muscimol-induced increase in Cl permeability, but it does not block the GABA- or baclofen-induced decrease in action potential duration. These functional and pharmacological differences between the two effects of GABA suggest that two separate receptors are involved.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.