Functional and Morphological Thyroid Disorders in Hemodialysis Patients

Abstract

Abstract Background: Chronic kidney disease (CKD) results in complex endocrine and metabolism alterations including thyroid dysfunction. There is many mechanisms explained the link between thyroid and kidney disease, both of them affect each other, plus both consider as an independent factor for cardiovascular disease. Aims: We investigate the prevalence of morphological and functional discarder in CKD maintained on hemodialysis and it relation to dialysis duration. Study design and method: A cross section study included 60 CKD patient maintained on HD and 40 control subjects. All subject investigated with thyroid ultrasound and thyroid hormone screen including serum thyroxine (T4), Triiodothyronin (T3), Thyroid stimulating hormone (TSH), free T3, free T4, Thyroglobulin antibodies (TG Ab) and Thyroid peroxidase antibodies (TPO Ab). Results: HD patients had a higher prevalence of diffuse goiter than control subjects (26.7% versus 10%, p=0.045), we compared the prevalence of thyroid function disorders between the two group which showed significant high frequency of low T3 syndrome in HD group. The mean duration of hemodilaysis was not significantly correlated with mean thyroid volume and TSH level (r=-0.06, r=0.13) respectively. While there was positive correlation between TSH level and mean thyroid volume among HD patients (r=0.25 p<0.05). Conclusions: We concluded that CKD patients maintained on HD were associated with higher prevalent thyroid function and morphology disorders in compared with healthy subjects.