Abstract
PURPOSE: High resolution MicroPET technology has recently been developed. 64Cu-DOTA-PEG-E[c(RGDyK)]2 (64Cu-RGD) is a cyclic RGD peptide that has previously demonstrated specific binding to ávâ3-integrin; a cell-cell adhesion molecule implicated in angiogenesis and metastasis, and expressed in many tumors including NSCLC. We studied the feasibility of serial MicroPET imaging in an orthotopic murine model of human lung cancer utilizing 18FDG and 64Cu-RGD.
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