Functional and anatomical magnetic resonance imaging: From Paediatrics to Psychiatry

Abstract

Event Abstract Back to Event Functional and anatomical magnetic resonance imaging: From Paediatrics to Psychiatry Cherine Fahim1* 1 Bâtiment Anthropole, Unil-Dorigny, Faculté des sciences sociales et politiques, Institut de psychologie et Faculté de Biologie et Médecine, Switzerland Two different studies will be presented: 1. The first study was conducted on a group of 23 children with a moderate score of depression- i.e. children who had sub-clinical symptoms of depression- using a DSM-IV based interactive interview for psychiatric and neurological symptoms were compared to 23 normal control children. All children were scanned using fMRI and DTI at the age of 8. The aim of the study was investigate if structural and functional differences related to depression could present at such an early age. We found abnormal function and structure in 6 out of 7 brain regions implicated in adult depression. 2. The second study investigated the effects of an antipsychotic (quetiapine) on the function and structure of the brain using fMRI and voxel based Morphometry after 5.5 months of treatment in a sub-group of schizophrenia patients (N=23) with blunted affect compared to schizophrenia patients without blunted affect. Clinically, patients receiving quetiapine showed a significant improvement in negative symptoms. Neurally, a significant increase in activity in brain region implicated in socio-emotional processing (orbitofrontal cortex, anterior cingulate cortex and fusiform gyrus) was detected following the treatment. In addition, grey matter densities in these same regions showed significant increase. The later two findings may explain the clinical improvement observed. Keywords: Depression, Neuroimaging, Schizophrenia Conference: 3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009. Presentation Type: Oral Presentation Topic: Symposium 16 – Neuroimaging in Paediatrics, Neurology and Psychiatry: from clinical phenomenology to neurobiological phenotypes; the Swiss Canadian Egyptian Neurodevelopemental Study (SCENS) Citation: Fahim C (2009). Functional and anatomical magnetic resonance imaging: From Paediatrics to Psychiatry. Front. Neurosci. Conference Abstract: 3rd Mediterranean Conference of Neuroscience . doi: 10.3389/conf.neuro.01.2009.16.062 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Nov 2009; Published Online: 19 Nov 2009. * Correspondence: Cherine Fahim, Bâtiment Anthropole, Unil-Dorigny, Faculté des sciences sociales et politiques, Institut de psychologie et Faculté de Biologie et Médecine, Lausanne 1015 Vaud, Switzerland, cherine.fahim@unil.ch Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Cherine Fahim Google Cherine Fahim Google Scholar Cherine Fahim PubMed Cherine Fahim Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.