Abstract
The histological and ultrastructural appearances of the normal arterial wall and of the two early lesions of atherosclerosis, the fatty streak and the fibrous plaque, will be described, and an account given of present knowledge of the functional capabilities of endothelial cells and of the magnitude and mechanism of leakage of macromolecules into the wall of normal arteries. With this background the basic features of the following hypotheses of atherogenesis will be discussed: a the lipid theory b the insudation theory c the focal injury theory of Ross and Mustard, and the possible causes of injury to arterial endothelium d the fatigue concept of arterial injury e Benditt's monoclonal hypothesis.
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