Abstract
In this research we utilized extracts from two different nature products, Achatina fulica and Heimiella retispora, to enhance skin moisturizing abilities, anti-oxidative properties, and cell proliferations. It was observed that two polysaccharides with anti-oxidative effects by chelating metal ions reduced oxidative stress and further blocked the formation of reactive oxygen species syntheses. To detect whether there was a similar effect within the cellular mechanism, a flow cytometry was applied for sensing the oxidative level and it was found that both materials inhibited the endogenous oxidative stress, which was induced by phorbol-12-myristate-13-acetate (PMA). Both polysaccharides also stimulated the production of collagen to maintain skin tightness and a moisturizing effect. In summary, we developed two macromolecular polysaccharides with potential applications in dermal care.
Highlights
The skin is the body’s largest organ
This study focuses on cell proliferation because cell proliferation is very important in the speed of wound repair
Ascorbic acid, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), L-3,4-dihydroxyphenylalanine (L-DOPA), dimethyl sulfoxide (DMSO), 1,1-diphenyl-2-picrylhydrazyl (DPPH), ethanol, ethylenediaminetetraacetic acid (EDTA), ferrous chloride (FeCl2 ·4H2 O), ferric chloride (FeCl3 ), kojic acid, methanol, potassium ferricyanide (K3 Fe(CN)6 ), 3-tert-butyl-4-hydroxyanisole (BHA), 5-hydroxy-2-hydroxymethyl-4-pyrone, 12-O-Tetradecanoylphorbol-13-acetate (PMA), and L-tyrosine were purchased from Sigma-Aldrich Company
Summary
The skin is the body’s largest organ It consists of three layers: The epidermis, dermis, and the subcutaneous tissue. The outer layer of the epidermis consists of dead skin cells, natural oils, and lipids to protect the skin from irritants and toxins and to prevent the loss of water, biomolecules, and electrolytes [1]. When the outer layer of the epidermis is exposed to some detergent and detergent ingredients, these protective elements on the surface of the skin are peeled off. Once these irritants penetrate the outer layers of the skin, they can cause dry skin and skin health problems. Constant water movement on the skin plays an important role in the epidermal repair process
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
