Functional analysis of glial genome-wide expression

Abstract

Event Abstract Back to Event Functional analysis of glial genome-wide expression Diego Forero1* and Rodrigo González-Reyes1 1 Universidad Antonio Nariño, Colombia Modern neurosciences have benefited from the recent development of high-throughput experimental platforms that allow the parallel analysis of thousands of molecules or regions of interest. Traditionally, these -omics experiments (transcriptomics, genomics, proteomics and epigenomics approaches) have been applied to neuronal cells. In this manuscript, we describe the aplication of four freely available tools for analysis of genome-wide expression data (Babelomics, DAVID, Galaxy and BioMart) to available datasets generated in glial cells. These analyses allow the identification of enrichment of functional categories, such as tissue specificity, transcriptional regulation, protein domains, signaling pathways and protein-protein interaction networks. Acknowledgements Work in the laboratories of D.A.F and R.G-R is supported by research grants from VCTI-UAN. References -Giardine B, Riemer C, Hardison RC, Burhans R, Elnitski L, Shah P, Zhang Y, Blankenberg D, Albert I, Taylor J, Miller W, Kent WJ, Nekrutenko A. Galaxy: a platform for interactive large-scale genome analysis. Genome Res. 2005 Oct;15(10):1451-5. -Schattner P. Automated querying of genome databases. PLoS Comput Biol. 2007 Jan 26;3(1):e1. -Fernández-Suárez XM, Birney E. Advanced genomic data mining. PLoS Comput Biol. 2008 Sep 26;4(9):e1000121. Keywords: Data Mining, Genomics and genetics, bioinformatics, Neurosciences, glial cells Conference: Latin-American School on glial cells in the diseased brain (IBRO), Bogotá, Colombia, 13 Jul - 17 Jul, 2015. Presentation Type: Oral Presentation Topic: Neural excitability, synaptic transmission, glia: Cellular and molecular mechanisms Citation: Forero D and González-Reyes R (2015). Functional analysis of glial genome-wide expression. Conference Abstract: Latin-American School on glial cells in the diseased brain (IBRO). doi: 10.3389/conf.fncel.2015.35.00024 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 20 Feb 2015; Published Online: 11 Jun 2015. * Correspondence: Dr. Diego Forero, Universidad Antonio Nariño, Bogotá, Colombia, diego.forero@uan.edu.co Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Diego Forero Rodrigo González-Reyes Google Diego Forero Rodrigo González-Reyes Google Scholar Diego Forero Rodrigo González-Reyes PubMed Diego Forero Rodrigo González-Reyes Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.