Abstract
Faithful chromosome segregation during cell division is fundamental for all living organisms. The bacterial parABS partitioning system is central to chromosome segregation and plasmid partitioning. The Bacillus subtilis ParB (BsParB) bacterial DNA-binding protein specifically recognizes parS DNA sites near the replication origin. BsParB spreads 10-20 kb from parS sites flanking the region, promoting recruitment of additional BsParB molecules to form higher-order nucleoprotein complexes essential for faithful chromosome segregation.
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