Abstract
A diversity of disease processes and conditions such as Alzheimer´s disease, schizophrenia, epilepsy and stroke – although they are caused by different mechanism – share one common target: the NMDA-receptor [1]. Recent studies reported the presence and the participation of this glutamate-gated ion-channel in major regulatory mechanisms at the blood-brain barrier (BBB). In order to show the functionability of this receptor and his effects on the BBB, we used an in vitro model based on human cell line ECV304 [2].
Highlights
Presented at the 21st Scientific Congress of the Austrian Pharmaceutical Society April 16th to April 18th 2009, Vienna, Austria
A diversity of disease processes and conditions such as Alzheimers disease, schizophrenia, epilepsy and stroke – they are caused by different mechanism – share one common target: the NMDA-receptor [1]
In order to show the functionability of this receptor and his effects on the blood-brain barrier (BBB), we used an in vitro model based on human cell line ECV304 [2]
Summary
Presented at the 21st Scientific Congress of the Austrian Pharmaceutical Society April 16th to April 18th 2009, Vienna, Austria. Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier Austria 2 PharmaCon GmbH, Riglergasse 4/5, 1180
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