Function of the human corpus luteum during the puerperium: Its maintenance by exogenous human chorionic gonadotropin

Abstract

The human corpus luteum is maintained and continues to function throughout pregnancy. Human chorionic gonadotropin (HCG) plays a major role in the maintenance of the corpus luteum until term. After delivery, the source of HCG disappears and the corpus luteum ceases to function. Daily administration of exogenous human chorionic gonadotropin in large doses for as long as 5 days post partum appeared to maintain the function of the corpus luteum and prevented the decline usually observed after delivery in untreated subjects. Corpus luteum function was assessed by means of two parameters: the measurement of progesterone concentrations in peripheral and ovarian venous plasma and synthesis of progesterone in vitro by surviving slices of corpus luteum tissue removed at various times post partum.