Function of the airway epithelium in asthma.

Teal S Hallstrand,Darryl A Knight,Prescott G Woodruff,Stephen T Holgate

doi:10.1155/2012/160586

Abstract

Function of the airway epithelium in asthma.

Highlights

In the paper entitled “Mechanisms of remodeling in asthmatic airways,” A
The review articles focus on mechanisms related to the epithelium including the response to fungal allergens, epithelial apoptosis, production of mediators involved in remodeling of the matrix, and the important role of epithelial injury and the production of interleukin 25 (IL25) in the induction phase of asthma
The article clearly delineates alterations in apoptosis that have been identified in human studies and in vivo animal models and the reasons that these alterations in the epithelium may play a pathogenic role in asthma and other lung diseases involving the epithelium

Summary

Introduction

In the paper entitled “Mechanisms of remodeling in asthmatic airways,” A. An increasingly strong body of evidence implicates the airway epithelium as a critical regulator of airway inflammation and remodeling relevant to the pathogenesis of asthma. The evidence implicating the epithelium includes in vivo studies in humans and in murine models as well as in vitro studies conducted with primary epithelial cells.

Results

Conclusion