Abstract
In this study, we investigated the anti-adhesive and anti-inflammatory effects of electrospun nanofibrous membranes made of polycaprolactone (PCL), poly-L-lactide (PLLA), poly (lactic-co-glycolic acid) (PLGA), and polyethersulfune (PES) in comparison with the oxidized-regenerated cellulose (Interceed). Using an adhesion induction model in mice, the membranes were sutured between the abdominal wall and peritoneum after surgical operation to reveal the best membrane for prevention of postoperative adhesion bands using two scoring adhesion systems. Compared with other membranes, PLGA, PCL, and Interceed membranes showed a greater ability to reduce adhesions. The lowest level of inflammation in adhesive tissues as well as cell attachment invitro was detected for PLGA nanofibrous membranes. These results suggested that in considering the FDA approved polymers, nanofibrous membranes prepared from PLGA exhibited the highest efficacy for the prevention of postoperative adhesion bands and hold promising potential for application as a new anti-adhesive agent.
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