Function of Centriolar Satellites and Regulation by Post-Translational Modifications.

Clotilde C. N. Renaud,Nicolas Bidère

doi:10.3389/fcell.2021.780502

Abstract

Centriolar satellites are small membrane-less granules that gravitate around the centrosome. Recent advances in defining the satellite proteome and interactome have unveiled hundreds of new satellite components thus illustrating the complex nature of these particles. Although initially linked to the homeostasis of centrosome and the formation of primary cilia, these composite and highly dynamic structures appear to participate in additional cellular processes, such as proteostasis, autophagy, and cellular stress. In this review, we first outline the main features and many roles of centriolar satellites. We then discuss how post-translational modifications, such as phosphorylation and ubiquitination, shape their composition and functions. This is of particular interest as interfering with these processes may provide ways to manipulate these structures.

Highlights

The centrosome is an organelle that consists of two structural sub-components: A pair of orthogonal centrioles, surrounded by a cloud of pericentriolar material
The deubiquitinating enzymes (DUBs) Cylindromatosis (CYLD) removes ubiquitin chains bound to Mindbomb 1 (MIB1) to limit its abundance and activity, preventing UbiquitinProteasome System (UPS)-mediated degradation of centriolar satellite components (Douanne et al, 2019)
It has become clear that these structures play a crucial role in maintaining centrosome homeostasis, in orchestrating ciliogenesis, and cellular proteostasis, the molecular basis behind these functions continues to be elucidated

Summary

Introduction

The centrosome is an organelle that consists of two structural sub-components: A pair of orthogonal centrioles, surrounded by a cloud of pericentriolar material. Centriolar satellites were shown to play a role in the cargo trafficking to the centrosome and the primary cilium, thereby orchestrating ciliogenesis (Figure 1) (Tollenaere et al, 2015a). We describe the main roles ascribed to centriolar satellites and discuss how post-translational modifications regulate their organization and functions.

Results

Conclusion