Abstract

PLGA/HA composite biomaterials are prepared, and 3D printing technology is used to make bone scaffolds that can be implanted in the body. Its performance is tested by in vitro physical and biological methods, and its safety is evaluated by animal experiments. Methods: 3D printing technology was used to print the PLGA/HA composite three-dimensional stent biomaterial, and the tensile strength and bending strength of the stent material were tested with reference to GB/T1040 and GB/T9341 to verify its ability to support the proliferation and differentiation of hMSC. The biological evaluation standard (GB/T16886) evaluates the biocompatibility and biosafety of scaffoldmaterials in vitro and in vivo. Results: The porous 3D scaffold made of PLGA/HA composite material was successfully fabricated; the mechanical tensile strength and flexuralstrength of the composite material were 38 MPa and 42 MPa respectively, which were5.35 times and 5.25 times that of normal human cartilage; in vitro cell test It is proved that the 3D scaffold can support the proliferation and differentiation of hMSC into chondrocytes. The results of the biosafety test show that the scaffold meets the national medical device biological evaluation standards.

Highlights

  • Bone tissue damage is a major problem facing human health

  • With the development of medical science, bone cement materials and artificial bone grafting technology have been widely used in clinical practice, but there are still some problems

  • The purpose of tissue engineering scaffold materials is to provide a three-dimensional scaffold for cells, which is conducive to cell adhesion, proliferation, and differentiation, and provides suitable environmental support for cell growth

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Summary

International Trends in Science and Technology

FUNCTION AND SAFETY EVALUATION OF 3D TECHNOLOGY TO PREPARE BONE REPAIR BIOMATERIALS Elcin Huseyn, Research Laboratory of Intelligent Control and Decision-Making Systems in Industry and Economics, Azerbaijan State Oil and Industry University, Baku, Azerbaijan, ORCID ID: https://orcid.org/0000-0001-5965-7419 DOI: https://doi.org/10.31435/rsglobal_conf/28022021/7433

Introduction
RS Global
Materials and methods
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