Abstract
During the fast paced multiplication of bacteria, cell growth, DNA replication, DNA segregation and cell division must occur and these essential processes must be coordinated temporally and spatially to achieve homeostasis. How this is achieved is not well understood. In the Gram-negative bacterium Caulobacter crescentus, the assembly and cellular positioning of the cytokinetic ring made of the tubulin homolog FtsZ is coordinated with chromosome origin segregation through the parS/ParB/MipZ kinetochore complex. We found that the polarity factor TipN plays a major role in the segregation of the parS/ParB/MipZ complex by affecting the dynamics of the ParA cytoskeletal element. This in turn governs the timing and placement of FtsZ ring formation, which ultimately affects cell growth, division and the size of the progeny.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
