FUNC SCORE IN PREDICTION INTRACEREBRAL HEMORRHAGE PATIENTS AT HUE CENTRAL HOSPITAL

Abstract

Introduction: Intracerebral hemorrhage (ICH) remains a cause of significant morbidity and mortality and is associated with long-term disability. Early neurological worsening (ENW) is a major determinant of death in ICH. Besides predicting morbidity, prognosis functional independence is a crucial matter. In 2008, Natalia Sana Rost created FUNC score to predict the likelihood of functional independence. The aim of our study was to evaluate the ability of FUNC score to predict three outcomes of ICH: Early neurological worsening, 30-day morbidity, and 90-day functional independence. And compare to ICH grading scales. Methods: We prospectively characterized 123 consecutive patients with ICH at Hue Central Hospital. ICH and FUNC scores were calculated. Receiver operating characteristic (ROC) analysis, including area under the curve (AUC), was used to assess the ability of each score to predict ENW, 30-day morbidity, and 90-day functional independence. Results: Overall, thirty-day mortality rate was 31.7% (n=39), while 48 (39.0%) patients had good outcome at 90-days (mRS ≤ 2). Thirty-three patients (26.8%) had ENW then all of them died at 30-days after ICH. Intraventricular bleeding involved significantly worse outcomes including ENW, mortality at 30-days after ICH, and poor outcome at 90-days. Worse outcomes had significantly bigger mean hematoma volume in all three outcomes. Both scores were accurate predictors of study outcomes demonstrating excellent discrimination (AUC > 0.80). And FUNC score, which had larger AUCs, predicted ENW, 30-day morbidity, and 90-day functional independence better than ICH score. Conclusions: FUNC scores are appropriate tools to predict ENW, with potential applications to clinical practice and research.