Abstract
The potential interactions of natively expressed μ-opioid and opioid receptor-like (ORL1) receptors were studied by exposing intact BE(2)-C cells to agonists or antagonists for 1 h. Pretreatment with the μ-opioid receptor agonist, [ d-Ala 2, N-Me-Phe 4,Gly 5-ol]enkephalin (DAMGO), or the ORL1 receptor agonist, orphanin FQ/nociceptin desensitized both μ-opioid and ORL1 receptor responses. β-Funaltrexamine (β-FNA) pretreatment also blocked both μ-opioid and ORL1 receptor responses, but only μ-opioid receptor binding was reduced. Moreover, β-FNA (1 μM) failed to inhibit specific ORL1 receptor binding.
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