Abstract
The genotoxicity of fumagillin was evaluated assessing the mitotic index and chromosome aberrations in mouse bone-marrow cells. Mice were given fumagillin orally in doses 5, 10 and 20 mg/kg bw. All doses significantly (p<0.001) reduced the mitotic index. The medium and maximum doses led to significant (p<0.01 and p<0.001, respectively) increases in numeric aberrations. The highest dose induced both structural and numeric aberrations (p<0.001), and insertions on the first pair of autosomes that were amplified in the 1C and 1E regions. These results pointed to the genotoxic potential of fumagillin in the range of medium and maximum doses applied. <br><br><font color="red"><b> This article has been retracted. Link to the retraction <u><a href="http://dx.doi.org/10.2298/ABS150320032E">10.2298/ABS150320032E</a><u></b></font>
Highlights
A in suppressing cryptosporidiosis and microsporidiosis caused by Enterocytozoon bieneusi which can be fatal in HIV-infected persons (Molina et al, R 2000; Conteas et al, 2000)
Fumagillin has been used in the treatment of microsporidiosis in fish including those caused by Myxobolus cerebralis (El-Matbouli and Hoffman, 1991; Karagouni et al, 2005) and Tetracapsuloides bryosalmona (Hedrick et al, 1988; Kent and Dawe, 1994; Le Gouvelo et al, at 80oC for 35 days (Assil and Sporns, 1991)
R All doses of fumagillin (Table 1) induced a acentrics and insertions remained similar to the numbers in the negative control; the same was true for aneuploidy and poliploidy (Table 2)
Summary
A in suppressing cryptosporidiosis and microsporidiosis caused by Enterocytozoon bieneusi which can be fatal in HIV-infected persons Fumagillin produced certain effects on the secretion granules of the hypopharyngeal glands of bees which increased and had a homogeneous structure, which is explained by the changes in the secretory activities of glands (Liu, 1990b). With syrup it is very effective in suppressing Nosema in hibernating honeybee colonies. It has not been effective against dormant spores of Nosema apis, or against Nosema ceranae
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