Abstract
HERPES-simplex virus was first isolated from a fever blister in 1919 by Lowenstein.1 This virus has been shown in more recent years to be the etiologic agent in acute infectious gingivostomatitis.2 3 4 5 In that these two entities are most commonly thought of when herpes simplex is mentioned, one tends to think of the virus more as a nuisance than as one causing fatal illness, although it is an occasional cause of encephalitis.6 Hass,7 however, in 1935, and, more recently, others8 9 10 11 12 13 14 15 16 17 reported cases of disseminated infection in premature and newborn infants. These investigators recorded a total of 19 cases with virus isolations . . .
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