Abstract
A newborn of normal birthweight received fresh blood transfusions and procoagulant fractions during his first days for a haemorrhagic disease. Three months later the infant had acute liver failure. Liver biopsy revealed a massive hepatic necrosis and an Australia antigen was detected. 1ml/kg of anti-HB gamma globulin was administered after each of two exchange transfusions (200 ml/kg). Anti-HB antibodies were detected after gamma globulin therapy. Once the passively administered antibodies had disappeared, the HB titer increased, and the child seemed physically and mentally normal seven months after the infection. These observations are difficult to interpret but immunity of the child seems possible.
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