Abstract
Current antiretroviral therapy has reduced morbidity and mortality of HIV patients. However, their induced hepatotoxicity constitutes a risk. In this issue, we report a clinical case of fulminant hepatitis, observed in the HIV unit of the hepatogastroenterology department of the General hospital of Loandjili in Pointe-Noire. The patient is a 36-year-old female HIV treated with triple-dug combination antiretroviral therapies (ART) including one antiprotease (ritonavir) and two non-nucleoside reverse transcriptase inhibitors (nevirapine and efavirenz). He developed fulminant hepatitis five years after treatment initiation. He succumbed to the side effects. Although antiretroviral combination therapies are the standard of care for HIV infection, increased vigilance is warranted to early identify this side effect and adjust treatment in order to prevent fatal consequences.
Highlights
Combination of antiretroviral therapies (ART) has transformed the natural history of human immunodeficiency virus (HIV) infection with a significant reduction in morbidity and mortality from opportunistic infections
We report a clinical case of fulminant hepatitis, observed in the HIV unit of the hepatogastroenterology department of the General hospital of Loandjili in Pointe-Noire
The patient is a 36-year-old female HIV treated with triple-dug combination antiretroviral therapies (ART) including one antiprotease and two non-nucleoside reverse transcriptase inhibitors
Summary
Combination of antiretroviral therapies (ART) has transformed the natural history of human immunodeficiency virus (HIV) infection with a significant reduction in morbidity and mortality from opportunistic infections. Some of the ARTs are labelled as hepatotoxic, constituting a potential risk for morbidity and mortality, especially in patients co-infected with the hepatitis B or hepatitis C viruses, and in alcoholic patients.
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