Abstract
During the past several years, there were few cases reported about the flutamide related hepatotoxicity. Most of them were reversible hepatocellular damage. Although flutamide induced fatal hepatocellular injuries were also found, there are extremely rare and never reported in Taiwan. Here, the development of fulminant hepatitis after 2 months of flutamide treatment in a 78-year-old man with pro- static carcinoma is reported. The patient eventually died of hepatic failure. Drug induced hepatitis was supported by pathologic evidences. This case strongly suggests that flutamide can induce acute hepatitis potentially with a fulminant and lethal course. Liver function tests should be monitored in patients receiving flutamide and the drug should be withdrawn if overt abnormal liver functions are found.
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