Abstract
BackgroundStaphylococcus aureus has emerged as a leading cause of invasive severe diseases with a high rate of morbidity and mortality worldwide. The wide spectrum of clinical manifestations and outcome observed in staphylococcal illness may be a consequence of both microbial factors and variability of the host immune response.Case presentationA 14-years old child developed limb ischemia with gangrene following S. aureus bloodstream infection. Histopathology revealed medium-sized arterial vasculitis. The causing strain belonged to the emerging clone CC1-MSSA and numerous pathogenesis-related genes were identified. Patient’s genotyping revealed functional variants associated with severe infections. A combination of virulence and host factors might explain this unique severe form of staphylococcal disease.ConclusionA combination of virulence and genetic host factors might explain this unique severe form of staphylococcal disease.
Highlights
Staphylococcus aureus has emerged as a leading cause of invasive severe diseases with a high rate of morbidity and mortality worldwide
Humans are a natural reservoir of S. aureus, which can occasionally cause diseases that range in severity from minor skin infections to severe cases of pneumonia, bacteremia and septic shock [1]
The severity and outcome of the infection relies on bacterial virulence, as S. aureus is known to have a wide arsenal of components that contribute to the pathogenesis of infection
Summary
Staphylococcus aureus has emerged as a leading cause of invasive severe diseases with a high rate of morbidity and mortality worldwide. Conclusion: A combination of virulence and genetic host factors might explain this unique severe form of staphylococcal disease.
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