Fully Synthetic 3D Fibrous Scaffolds for Stromal Tissues—Replacement of Animal‐Derived Scaffold Materials Demonstrated by Multilayered Skin (Adv. Mater. 10/2022)

Abstract

Porous Fibrous Scaffolds The dimensions of electrospun fibers are predestined for synthetic replacement of extracellular matrix structures. In article number 2106780, Tobias Weigel and co-workers generate highly porous electrospun scaffolds, featuring an ensemble of loose fibers and pores of appropriate size to enable applications in engineering animal-free 3D biomedical tissues. The mechanical properties and structural composition describe a tradeoff between current synthetic porous scaffolds and animal-derived hydrogels, which are deployed as electrospun-based multilayered skin equivalents.