Abstract
The widely used bifunctional labeling reagent 4-[ 18F]fluorobenzoic acid ([ 18F]FBA) and its activated form N-succinimidyl 4-[ 18F]fluorobenzoate ([ 18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [ 18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77±5% ( n=4) for [ 18F]FBA and 46±5% ( n=4) for [ 18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.
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