Abstract
An automated synthesis protocol is developed for the synthesis of block copolymers in a multi-step approach in a fully automated manner. For this purpose, an automated dialysis setup is combined with robot-based synthesis protocols. Consequently, several block copolymerizations are executed completely automated and compared to the respective manual synthesis. As a result, this study opens up the field of autonomous multi-step reactions without any human interactions.
Highlights
Block copolymers are macromolecules with at least two different blocks of monomers that are linearly and/or radially connected [1,2]
An automated synthesis protocol is developed for the synthesis of block copolymers in a multi-step approach in a fully automated manner
An automated dialysis setup is combined with robot-based synthesis protocols
Summary
Block copolymers are macromolecules with at least two different blocks of monomers that are linearly and/or radially connected [1,2]. In order to obtain well-defined products with a small dispersity, living ionic [2,10–12] and controlled radical polymerizations [13,14] are the most successful and utilized approaches Those techniques were utilized in flow chemistry to produce block copolymers rapidly. These approaches are limited to monomers that reach a high conversion to avoid purification and isolation protocols [15,16]. Haven and coworkers created a quasi-block copolymer library in a one-pot HTE approach utilizing an automated synthesizer. They still avoided purification steps by assuming a full monomer conversion [27]. Several block copolymerizations are performed manually and automatically to prove the potential of the developed technology
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