Fullerene hexa-adduct scaffolding for the construction of giant molecules.

Abstract

Hexa-substituted fullerenes are unique scaffolds for the fast construction of globular dendrimers. Efficient synthetic methodologies based on the post-functionalization of pre-constructed fullerene hexa-adduct derivatives have been reported in recent years and dendrimers difficult or even impossible to prepare by classical fullerene chemistry are now easily accessible. Fullerodendrimers for various applications have been thus prepared. Examples include liquid crystalline materials, non-viral gene delivery systems and bioactive glycoclusters. On the other hand, fullerene hexa-adduct building blocks have been used for the ultra-fast synthesis of giant dendrimers. Indeed, the resulting dendrimers of first generation are already surrounded by 120 peripheral functional groups. This strategy has been used to prepare giant glycoclusters with anti-viral activity and multivalent glycosidase inhibitors.