Fullerene derivatized s-triazine analogues as antimicrobial agents

Abstract

A series of novel fullerene derivatives bearing s-triazine moiety have been synthesized by adopting 1,3 dipolar cycloaddition reaction of C 60 and azomethine ylides generated from the corresponding Schiff bases of 2,4,6 trisubstituted s-triazine. All the compounds synthesized were characterized by elemental analysis, FT-IR, 1H NMR, 13C NMR and FAB-MS. The compounds were then screened for their antibacterial activity against both gram-positive ( Staphylococcus aureus, Bacillus subtilis, Bacillus pumilis) and gram-negative ( Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacteria by disc diffusion method. All the compounds were found to be active against these strains at very low concentration and were comparable to standard drug ciprofloxacin.