Abstract
The aim of this randomized controlled clinical trial was to evaluate the clinical effects of chlorhexidine (CHX) application in a full-mouth disinfection (FMD) protocol in poorly controlled type-2 diabetic subjects with generalized chronic periodontitis. Thirty-eight subjects were randomly assigned into FMD group (n=19): full-mouth scaling and root planing (FMSRP) within 24h + local application of CHX gel + CHX rinses for 60days or Control group (n=19): FMSRP within 24h + local application of placebo gel + placebo rinses for 60days. Clinical parameters, glycated haemoglobin and fasting plasma glucose were assessed at baseline, 3, 6 and 12months post-therapies. All clinical parameters improved significantly at 3, 6 and 12months post-therapies for both groups (p<0.05). There were no significant differences between groups for any clinical parameters, and glycemic condition at any time-point (p>0.05). The treatments did not differ with respect to clinical parameters, including the primary outcome variable (i.e. changes in clinical attachment level in deep pockets), for up to 12months post-treatments.
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