Abstract
The species Corriparta virus (CORV), within the genus Orbivirus, family Reoviridae, currently contains six virus strains: corriparta virus MRM1 (CORV-MRM1); CS0109; V654; V370; Acado virus and Jacareacanga virus. However, lack of neutralization assays, or reference genome sequence data has prevented further analysis of their intra-serogroup/species relationships and identification of individual serotypes. We report whole-genome sequence data for CORV-MRM1, which was isolated in 1960 in Australia. Comparisons of the conserved, polymerase (VP1), sub-core-shell ‘T2’ and core-surface ‘T13’ proteins encoded by genome segments 1, 2 and 8 (Seg-1, Seg-2 and Seg-8) respectively, show that this virus groups with the other mosquito borne orbiviruses. However, highest levels of nt/aa sequence identity (75.9%/91.6% in Seg-2/T2: 77.6%/91.7% in Seg-8/T13, respectively) were detected between CORV-MRM1 and California mosquito pool virus (CMPV), an orbivirus isolated in the USA in 1974, showing that they belong to the same virus species. The data presented here identify CMPV as a member of the Corriparta virus species and will facilitate identification of additional CORV isolates, diagnostic assay design and epidemiological studies.
Highlights
Corriparta viruses are mosquito-borne arboviruses, classified within one of the 22 virus species currently recognised within the genus Orbivirus, family Reoviridae
We report the full genome sequence of Corriparta virus (CORV)–MRM1 (AUS1960/01)
The viral dsRNA was purified from infected cell-cultures and analysed by 1% agarose gel electrophoresis (AGE) (Figure 1)
Summary
Corriparta viruses are mosquito-borne arboviruses, classified within one of the 22 virus species currently recognised within the genus Orbivirus, family Reoviridae. The structural and chemical properties of the corriparta viruses are similar to those of other orbiviruses [2]. They are sensitive to low pH and heat, and can be modified by treatment with trypsin or chymotrypsin [10]. They have been shown to multiply in mosquitoes after intra-thoracic inoculation [10]
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