Abstract
We present the complete genome sequence of bovine alphaherpesvirus 2 (BoHV-2), a member of the family Herpesviridae, subfamily Alphaherpesvirinae, genus Simplexvirus. BoHV-2 is the causative agent of bovine ulcerative mammillitis (bovine herpes mammillitis) and pseudo-lumpy skin disease. The genomic architecture of BoHV-2 is typical of most simplexvirus genomes and congruent with that of human alphaherpesvirus 1 (HHV-1). The genome comprises a total of 131,245 base pairs and has an overall G+C content of 64.9 mol%. A total of 75 open reading frames are predicted. The gene repertoire of BoHV-2 is analogous to that of HHV-1, although the coding region of US12 is missing. A phylogenetic analysis supported BoHV-2 as a member of the genus Simplexvirus.
Highlights
Infection with bovine alphaherpesvirus 2 (BoHV-2), referred to as bovine mammillitis virus or Allerton virus, causes acute viral diseases in cattle that may develop two separate syndromes: ulcerative mammillitis or pseudo-lumpy skin disease [1,2,3]
Pseudolumpy skin disease is a generalized form of BoHV-2 infection that causes mild fever and distinct nodular lesions of the skin, comparable to those present during lumpy skin disease [4, 5]
Epidemiological data are unsatisfactory for BoHV-2, phylogenetic analysis is mainly based on partial sequences of glycoprotein B (gB), and no full-length BoHV-2 genome sequence is available
Summary
Infection with bovine alphaherpesvirus 2 (BoHV-2), referred to as bovine mammillitis virus or Allerton virus, causes acute viral diseases in cattle that may develop two separate syndromes: ulcerative mammillitis (bovine herpes mammillitis) or pseudo-lumpy skin disease [1,2,3]. Epidemiological data are unsatisfactory for BoHV-2, phylogenetic analysis is mainly based on partial sequences of gB, and no full-length BoHV-2 genome sequence is available. Extracted DNA was used for Illumina 150-bp paired-end sequencing, resulting in about 6.4 and 7.4 million read pairs for C1Z FZR and Riems 8/85, respectively.
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