Abstract
Fucoxanthin is one of the most abundant carotenoids and possesses a number of beneficial medicinal qualities which include its anti-oxidant, anti-obesity and anti-cancer properties. In this study, the photostability of fucoxanthin in extracts with different chemical profiles was studied. The extracts were obtained from Undaria pinnatifida, a seaweed rich in this carotenoid, using conventional liquid solvent extraction procedures and the QuEChERS method. All the extracts contained all-trans-fucoxanthin as the major compound. Conventional procedures produced a fucoxanthin purity of lower than 50%, whereas after liquid-liquid partition, PSA cleanup, and PSA and GCB cleanup (QuEChERS method) fucoxanthin purity increased to 70%, 86%, and 94%, respectively. Although in the acetone extract the initial content of fucoxanthin was the highest, results demonstrate that coextractives play an important role in enhancing the rate of photodegradation. After light exposure, the conventional extracts lost around 90% of the initial fucoxanthin content. On the other hand, the extracts obtained by the QuEChERS method showed significantly higher light stability than the conventional extracts. These results suggest that the QuEChERS method could be used and further improved to obtain more purified and stable extracts for fucoxanthin from U. pinnatifida.
Highlights
Fucoxanthin is one of the most abundant carotenoids, and contributes to more than 10% of the estimated total production of carotenoids in Nature, especially in the marine environment [1].Fucoxanthin is a pigment, along with chlorophylls and β-carotene, widely distributed in brown algae and diatoms [2]
The photostability of the fucoxanthin in Undaria pinnatifida extracts with different chemical profiles was studied
The QuEChERS method is the most commonly applied prep method for the determination of pesticide residues from a variety of fruit and vegetables, fatty food matrixes like milk and eggs, and water [28]. This method involves an extraction with acetonitrile partitioned from the aqueous matrix using anhydrous magnesium sulphate (MgSO4) and sodium chloride (NaCl) followed by a dSPE cleanup with MgSO4 and primary secondary amine (PSA) or a combination of PSA and graphitized carbon black (GCB)
Summary
Fucoxanthin is a pigment, along with chlorophylls and β-carotene, widely distributed in brown algae and diatoms [2] It has an unusual structure with an allenic bond and 5,6-monoepoxide in its molecule (Figure 1). Fucoxanthin provides protective effects on liver, blood vessels of the brain, bones, skin and eyes It has anti-obesity and anti-diabetic properties, and anti-inflammatory and anti-malarian effects. It has been demonstrated that pretreatment with fucoxanthin improves the chemotherapeutic efficacy of cisplatin by enhancing the inhibition of cell proliferation of human hepatoma HepG2 These results suggest that the combined treatment of fucoxanthin and cisplatin may provide a novel therapeutic approach to decrease cisplatin-induced drug resistance [11,12]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
