Fucophlorethol C, a phlorotannin as a lipoxygenase inhibitor.

Hideyuki Kurihara,Koretaro Takahashi,Remi Konno

doi:10.1080/09168451.2015.1062716

Hideyuki Kurihara, Koretaro Takahashi + Show 1 more

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https://doi.org/10.1080/09168451.2015.1062716

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Abstract

Fucophlorethol C, a phlorotannin, was isolated from the brown alga Colpomenia bullosa (Scyto-siphonaceae) as a novel lipoxygenase (LOX) inhibitor. It was obtained as a free form from natural origin for the first time. The compound inhibited a soybean LOX to the same extent as the known inhibitor nordihydroguaiaretic acid.

Highlights

Lipoxygenase (LOX) mediates formation of hydroperoxides of unsaturated fatty acids
Nordihydroguaiaretic acid (NDGA) is a known inhibitor isolated from Zygophyllaceae plant.4)
nordihydroguaiaretic acid (NDGA) shows toxic effect when patients use this plant and NDGA during long time.5) a few studies have been performed on LOX inhibitors originated from algae.6,7) Recently we have isolated alkapolyenes and pheophytin a as LOX inhibitors from the brown alga Sargassum thunbergii and the red alga Odonthalia corymbifera, respectively.8) In the present study, fucophlorethol C (1, Fig. 1), a phlorotannin, was isolated as a novel LOX inhibitor from the brown alga Colpomenia bullosa (Scytosiphonaceae)

Summary

Introduction

Lipoxygenase (LOX) mediates formation of hydroperoxides of unsaturated fatty acids. The hydroperoxides are converted to leukotrienes, related to various diseases, psoriasis, asthma, rhintis, and arthritis.1). The inhibitors have been obtained from terrestrial plants.2,3) Nordihydroguaiaretic acid (NDGA) is a known inhibitor isolated from Zygophyllaceae plant.4) This is the first report on isolation of fucophlorethol C as a free form.

Results

Conclusion