Abstract
Chronic wounds have become a serious global health issue. This study investigated the effects of increasing fucoidan (FD) concentration on the characteristics of nanofibers and their potential in wound dressings in vitro as well as in vivo. The results showed that increasing FD content (0.25 to 1%) led to an increase in nanofiber diameter (487.7±125.39 to 627.9±149.78 nm), entrapment efficiency (64.26±2.6 to 94.9±3.1%), and water uptake abilities significantly (436.5±1.2 to 679.7±11.3%). However, the in vitro biodegradation profile decreased with an increase in FD concentration. Water vapor transmission rate analysis showed that it was within the standard range for all FD concentrations. Nanofibers with 1% PVA/DX/FD exhibited slow-release behavior, suggesting prolonged FD availability at the wound site. In vivo studies in rats with full-thickness wounds demonstrated that applying 1% FD-enriched PVA/DEX nanofibers significantly (p < 0.0001) improved mean wound area closure. These findings suggest that FD-enriched nanofibers have immense potential as a wound dressing material in future if explored further.
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