Abstract

AbstractFTIR spectroscopy has been used to study the three self‐complementary oligonucleotides TGATCA, CGATCG, and TGTACA in the form of complexes with the anthracycline drug nogalamycin. These complexes were prepared under conditions that enable the bulky nogalamycin to intercalate into the double helixes of the oligonucleotide duplexes. Changes in the FTIR spectra on complexation are indicative of strong perturbation of the AT base pairs, in contrast with the effect of the structurally related drugs adriamycin and daunamycin, which show affinity for GC base pairs. These differences are attributed to binding interactions with the functional groups attached to the aglycone chromophore rather than to the specific site of drug intercalation in the double helix. © 1995 John Wiley & Sons, Inc.

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