FTIR, 1H NMR, ESR, TGA and DTA Analysis of Trithiocarbonates of Captopril and 6‐Mercaptopurine as Their Palladium(II) Chloride Complexes

Abstract

AbstractA simple and sensitive spectrophotometric method has been developed for the determination of the antihypertensive drug captopril and anticancer drug 6‐mercaptopurine, in their trithiocarbonate (TTC) form by using Pd(II) chloride as a coloring reagent. Captopril TTC forms a stable dark yellow colored complex with λmax 383 nm, molar absorption coefficient 1.35 × 105 l/mole/cm and a Beer's law range from 0.084‐1.26 ppm. 6‐Mercaptopurine TTC forms a stable deep yellow colored complex with λmax 345 nm, molar absorption coefficient 6.9 × 105 l/mole/cm and a Beer's law range from 0.0319 ppm to 3.519 ppm. The M: L ratio of palladium: TTC complexes were confirmed by Job's method of continuous variance and mole ratio method and was found to be 1:1 for both captopril TTC as well as 6‐mercaptopurine TTC. In addition, on the basis of, FTIR, 1H NMR, ESR and thermal analysis data a plausible structure of mononuclear Pd(II) complex of Captopril TTC and 6‐mercaptopurine TTC has been reported.