Abstract
AbstractRaman and surface‐enhanced Raman scattering (SERS) spectroscopies were employed to probe the interaction of the antimalarial drugs chloroquine (CQ) and mefloquine (MQ) with hematin. NIR‐SERS spectra of both quinoline derivatives were obtained from a colloidal gold surface. Strong chemical interactions of each drug with the Au particles are observed and the similarities of the two NIR‐SERS spectra allowed to predict a similar orientation geometry for both of the drugs on the colloidal surface, namely through the quinoline skeletal part of each molecular structure.Separately, the adsorption behavior of hematin on the Au colloid was studied under nonresonant conditions. In addition, both hematin–antimalarial drug systems (CQ and MQ) were prepared and investigated by NIR‐SERS. Copyright © 2006 John Wiley & Sons, Ltd.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
