Abstract
New, simple and cost effective infrared spectroscopic method has been developed for the estimation of zidovudine (CAS 30516-87-1) in bulk and tablet dosage form. The quantitative analysis of zidovudine was carried out in solid form using KBr pellet method and in liquid form using quartz cuvette. These methods were developed and validated for various parameters according to ICH guidelines. Linearity range was found to be 0.8-1.6% w/w in KBr pellet method and 250-1 500 μg ml-1 in solution. The proposed methods were successfully applied for the determination of zidovudine in pharmaceutical formulation (tablets). The results demonstrated that the proposed methods are accurate, precise and reproducible (relative standard deviation<2%), while being simple, economical and less time consuming than other available methods and can be used for estimation of zidovudine in different dosage forms.
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