FSRD: fungal stress response database

Z Karanyi,I Pocsi,L Hornok,M Miskei,I Holb

doi:10.1093/database/bat037

Abstract

Adaptation to different types of environmental stress is a common part of life for today’s fungi. A deeper understanding of the organization, regulation and evolution of fungal stress response systems may lead to the development of novel antifungal drugs and technologies or the engineering of industrial strains with elevated stress tolerance. Here we present the Fungal Stress Response Database (http://internal.med.unideb.hu/fsrd) aimed to stimulate further research on stress biology of fungi. The database incorporates 1985 fungal stress response proteins with verified physiological function(s) and their orthologs identified and annotated in 28 species including human and plant pathogens, as well as important industrial fungi. The database will be extended continuously to cover other fully sequenced fungal species. Our database, as a starting point for future stress research, facilitates the analysis of literature data on stress and the identification of ortholog groups of stress response proteins in newly sequenced fungal genomes.Database URL: http://internal.med.unideb.hu/fsrd

Highlights

In terms of geological times and evolutionary events, plants taking part in the terrestrialization in the Ordovician– Devonian (480–430 Mya) had to face a basically harsh environment with water and nutrient limitations, UV radiation, temperature stress, hostile microbes and the deleterious effects of the oxidative atmosphere [1]
Fungal stress response proteins were collected from the AmiGO database [39]
The identified orthologs are presented in the Fungal Stress Response Database (Figure 3; http://in ternal.med.unideb.hu/fsrd), where 29 723 orthologs of the 1985 stress response proteins can be found in 28 species

Summary

Introduction

In terms of geological times and evolutionary events, plants taking part in the terrestrialization in the Ordovician– Devonian (480–430 Mya) had to face a basically harsh environment with water and nutrient limitations, UV radiation, temperature stress, hostile microbes and the deleterious effects of the oxidative atmosphere [1]. Considering the topics, common stress types like osmotic stress, nutrient-deprivation stress, heat shock, DNA damage and oxidative stress have been dominating the majority of the articles published on fungal stress responses in the past decade.

Results

Conclusion