Abstract
ABSTRACT Objective: Gonadotropinomas with signs related to hypergonadotropinemia have been rarely published. We report 2 clinical cases of follicle-stimulating hormone (FSH)-producing macroadenomas showing manifestations of hormone hypersecretion. Methods: The clinical, laboratory, and imaging findings are presented with a review of the literature. Results: A 51-year-old man was admitted to the hospital because of cranioencephalic trauma following seizures. He reported previous altered behavior, depression, sphincter incontinence, and visual troubles. Physical examination revealed signs of hypogonadism and increased bilateral testicular volume. Magnetic resonance imaging (MRI) showed a large lesion in the sellar-suprasellar area, with mass effect. Hormone testing showed high levels of FSH (517 mIU/mL) and low levels of both luteinizing hormone (LH) (2.2 mIU/mL) and testosterone (1.3 ng/mL). A partial resection of an immunopositive FSH adenoma was performed; FSH declined after surgery, but the patient died...
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