Abstract
Plasma immunoreactive estrogen was significantly lower on days 9 and 8 before menstruation in a group of 15 women with premenstrual tension (PMT) syndrome, than in a control group of 17 women. Estrogen thereafter started to increase and was significantly higher in the PMT-group than in the controls on day 5 before menstruation. This increase was significant until day 1 before menstruation. Progesterone levels were constantly lower in the PMT-group than in the controls. The mean FSH level in plasma in PMT patients was significantly increased above controls on day 9, 8, 7 and 6 before menstruation. No difference between groups was seen in LH levels nor in serum albumin and binding capacity of testosterone-estradiol binding globulin (TeBG), neither could changes in LH, albumin or TeBG capacity explain the increase seen in estrogen concentration. The possible role of FSH in the PMT syndrome is discussed in order to explain the increased estrogen secretion.
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