FS03.2 Visual scoring of skin irritation reactions – what are the limits?

Abstract

We have previously reported that, with suitable training and experience, skin irritation reactions can be graded visually with a high degree of sensitivity and precision. The objective of the work presented is to demonstrate the possibilities and limitations of the grading of skin irritation reactions by subjective visual assessment. In the present work, we have recorded a wide range of relatively minor skin irritation reactions using a high quality digital camera. The skin reactions recorded have then been graded by independent observers according to their appearance on a computer monitor. The results show that very subtle degrees of both erythema and skin dryness can be accurately described by trained skin graders in a reliable and reproducible manner. Examples of the grading scales and sensitivity of scoring will be shown. We conclude that visual scoring, when conducted well, represents a rapid and accurate method for the assessment of minor degrees of skin irritation. The present evidence, taken in combination with previously presented information on bioengineering techniques, leads us to the conclusion that visual assessment is both an adequate and a robust technique, delivering information of the quality necessary for safety assessment of consumer products.