Abstract
AbstractHere we employed Al(C6F5)3/Mes3P frustrated radical pair (FRP) to catalyze hydrodehalogenation reaction. Through the initiation of the FRP, stannane radicals were generated to facilitate the halogen‐atom transfer (XAT) process and proceed the hydrodehalogenation of a wide range of alkyl and aryl halides under visible light at room temperature. Electron paramagnetic resonance (EPR) experiment, radical clock reaction coupled with control experiments provide solid evidence to support the radical mechanism. Moreover, this strategy can be applied to the synthesis of pharmaceutical compounds, such as indoles and quinolines as well as the deuterated compounds.
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