Abstract
Fruit juice of Citrus limon (lemon juice) has been utilized as a natural and renewable catalyst for the green and environmentally friendly preparation of 3,4-disubstituted isoxazol-5(4H)-one derivatives and 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives in hydroalcoholic media at 90 °C. A one-pot three-component reaction of β-oxoesters with hydroxylamine hydrochloride and various aromatic aldehydes afforded 3,4-disubstituted isoxazole-5(4H)-one derivatives in excellent yields. The rate constant (K = 6.12 × 10−2 min−1 at 25 °C) for the formation of isoxazole derivative (1g) was also calculated. Similarly, a four-component reaction of ethyl acetoacetate, hydrazine hydrate, aryl aldehydes, and malononitrile gives pyrano[2,3-c]-pyrazole derivatives in very good yields. After completion of the reaction, the products were isolated by simple filtration. A simple work-up process, high product yields, short reaction times, and the use of an inexpensive and biodegradable catalyst are the advanced rewards of the present protocol.
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